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Directly act on the cells (Cytotoxic Drugs). Clinical use evolved from the observation of bone marrow suppression and lymph node shrinkage in soldiers exposed to sulfur mustard gas warfare during World War I. Effectiveness as anticancer agents was confirmed by clinical Examples of alkylating agents include chlorambucil, cyclophosphamide, thiotepa, and busulfan. Se hela listan på microblife.in Se hela listan på cancer.org For example, the therapeutic index of alkylating agents should improve if the alkylation of tumor cells were increased without a simultaneous increase in normal tissue alkylation. This might be accomplished by maneuvers designed to inhibit drug activation by glutathione or GST P1, 86 or by blocking the repair processes, as discussed below. Se hela listan på wikilectures.eu 2020-12-31 · Alkylating antineoplastic agent An alkylating antineoplastic agent is an alkylating agent that attaches an alkyl group to DNA. Since cancer cells generally proliferate unrestrictively more than do healthy cells they are more sensitive to DNA damage, and alkylating agents are used clinically to treat a variety of tumours. Effects of buffer composition on water stability of alkylating agents. The example of N-ethyl-N-nitrosourea.

Alkylating agents examples

N-mustard. add alkyl groups to DNA by acting as electrophiles. busulfan, carmustine, chlorambucil, estramine Alkylating Agents. Alkylating agents are most active in the resting phase of the cell. These types of drugs are cell-cycle non-specific.

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alkylamino. alkylammonium. alkyl aryl sulfonate. alkylating agent.

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Cyclophosphamide — the most widely used alkylating agent of modern times. Some examples of alkylating agents are nitrogen mustards (chlorambucil and cyclophosphamide ), cisplatin, nitrosoureas (carmustine, lomustine, and semustine), alkylsulfonates (busulfan), ethyleneimines (thiotepa), and triazines (dacarbazine). Alkylating agents in the classic family include nitrogen mustard, cyclophosphamide, Examples of alkylating agents Basic Conditions Neutral Conditions Acidic Conditions Me-I Diazomethane: CH2N2 MeOH/H + Me-OTs, Me-OMs TMSCHN2 MeOH/BF3 Carboplatin, cisplatin, oxaliplatin. Nonclassical alkylators. Altretamine, dacarbazine, procarbazine. The major clinical toxicities of most of the alkylating agents are similar to those of mechloramine, primarily bone marrow depression (including anemia, leukopenia, and thrombocytopenia) and nausea and vomiting. Any alkylating agent is a potential hazard, however, because they are quite capable of alkylating DNA or other chemicals in the human body, thereby changing their nature and upsetting a person's biochemistry.

3 rows The major clinical toxicities of most of the alkylating agents are similar to those of mechloramine, primarily bone marrow depression (including anemia, leukopenia, and thrombocytopenia) and nausea and vomiting. As noted above, alkylating agents generally have … Alkylating agents, for example nitrogen "mustards", are variably toxic, mutagenic, carcinogenic and teratogenic, but by mechanisms which have not been clearly established.
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Clinical use evolved from the observation of bone marrow suppression and lymph node shrinkage in soldiers exposed to sulfur mustard gas warfare during World War I. Effectiveness as anticancer agents was confirmed by clinical Examples of alkylating agents include chlorambucil, cyclophosphamide, thiotepa, and busulfan. Se hela listan på microblife.in Se hela listan på cancer.org For example, the therapeutic index of alkylating agents should improve if the alkylation of tumor cells were increased without a simultaneous increase in normal tissue alkylation. This might be accomplished by maneuvers designed to inhibit drug activation by glutathione or GST P1, 86 or by blocking the repair processes, as discussed below.
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MOST AGENTS ▷ Swedish Translation - Examples Of Use Most

alkylation. alkylbenzene. alkylbenzene sulfonate.